WPCJ VORQeVI)ߘPEV.M0kzṼ8sOk(Tĭ&܆/E}i;uU\3} LbI~y}g L'QK(:rgִ֥ n,Ĥ~g R_֞j Y@a#QOD{ @}0 gN0c0l ֣Xt~GW6jr6,DxUq᳃P.p'Gl%8c!F_~D*,Tލ?Z>lU鹵^x>omriɵ^6-Nf"Q-"+嬚S!#!UN %= 0(C k 0PMEwd m (4( D3)UNA))U:)U:)*U:*+U:++U:,,-.N/0U:0 B1(11 0DY3U:3 D+34U:4 AQ485 0D5 0DB6 D/6 B66U:77U:88U:99:U:v;;U:|<<>U:??@U:AA{AGB D3C BECU:bCCU:gDgDDU:kEkEU:EEFuGHU:HNIU:IIU:OIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIOIIIU:eJU:JHP LaserJet III,,,,,,0(hH  Z 6Times New Roman RegularX($ /Q+ d  _,,s&=-)h|  pELLs &&,&,&s&;=-)h|U0+ pEE91+E91+s&K#QA=h|b0 `XEF1F1q&L;+'h|$H0E `EF%P1EEtF%P1Eqs&8=-)h| " pE"""s %&%&&&A),|/dE,|/AA)&|/dE&|/AA),%dE,%AA),O1%dE,O1%AA),%dE,%A &&%&%&s&7=-)h|>' pEjjsp&::*&hx8  pE],  ], ps&>=-)h|    pEL   L  ss&I= -)h|sm  pEm m m ss&B= -)h|    pEL   L   ss&J= -)h| ]  pE] ] ]  ss&E= -)h|s  pE    ss&== -)h| ;  pE; ; ;  sA)lXdElXAA)hXdEhXAA)lXdFElXAA)hXdFEhXAA),l%dFE,l%AA),%dFE,%AA),h%dFE,h%AA),%dFE,%A((3/Q$ !   d EEEEU /Q+ d  _,,s& =-)h|  pELLs &&,&,&s&=-)h|U0+ pEE91+E91+s&#QA=h|b0 `XEF1F1q&;+'h|$H0E `EF%P1EEtF%P1Eqs&=-)h| " pE"""s %&%&&&A),|/dE,|/AA)&|/dE&|/AA),%dE,%AA),O1%dE,O1%AA),%dE,%A &&%&%&_s& =-)h|>' pEjjs_p&$:*&hx8  pE],  ], ps&,=-)h|    pEL   L  ss&.= -)h|sm  pEm m m ss&0= -)h|    pEL   L   ss&2= -)h| ]  pE] ] ]  ss&3= -)h|s  pE    ss&5= -)h| ;  pE; ; ;  sA)lXdElXAA)hXdEhXAA)lXdFElXAA)hXdFEhXAA),l%dFE,l%AA),%dFE,%AA),h%dFE,h%AA),%dFE,%A _^*_XX^__^*^__^NAME (  #^__ ^N##X|X_^#€$Y 'dxd(hH  Z 6Times New Roman Regular3|x,  AZ"Arial Regular,  AZ"Arial Regular _,,XX,A,,, (  VAForm  Jun1990#,,,1,A/#,  AZ"Arial Regular ("  _]PXX K]P1013138#]PMKM# - AZ"Arial Regular _,,XX (  ,A,,,Page8#,,,O,AJ##XX,,#,  AZ"Arial Regular ("  _  X|XXX X9X|INVESTIGATORSTOTALVAANDNONVARESEARCH/DEVELOPMENTSUPPORT#X|X 9V#ԁLevel 1Level 2Level 3Level 4Level 5Level 1Level 2Level 3Level 4Level 5Level 1Level 2Level 3Level 4Level 5Level 1Level 2Level 3Level 4Level 5,  AZ"Arial Regular d _^*_XX"^__^* (  1.Provideadetailedexplanationofthescientificandbudgetaryrelationshipofeachprogram/projectlistedon_VAF_Ԁ1013137  ЀtotalVAProgram.2.In_cloumn_Ԁbelowlabeled STATUS,insertoneofthefollowing:VA(VA):G(government):NG(nongovernment):P(pending).#^*__G^/##XX_^*#(3$ !  ,  AZ"Arial Regular'dxd _^*_XX%^__^*INSTRUCTIONS:#^*__<^/##XX_^*#,  AZ"Arial Regular'(!)C<<CLevel 1Level 2Level 3Level 4Level 5(3$ !  ($$   1  ++' dxdP Pd _  -X|XXX-^_XAX| (  STATUS#-X|X_A^;##XXXAX|#,  AZ"Arial Regular _^*_XX/^__^* (  GRANT/PROJECTNO.#^*__C^/##XX_^*#,  AZ"Arial Regular _  /X|XXX/^_XCX| (  STATUS#/X|X_C^;##XXXCX|#,  AZ"Arial Regular _^*_XX/^__^* (  GRANT/PROJECTTITLE#^*__C^/##XX_^*# _^*_XX4^__^* (  GRANT/PROJECTNO.#^*__H^/##XX_^*#,  AZ"Arial Regular _^*_XX6^__^* (  GRANT/PROJECTTITLE#^*__F^/##XX_^*#,  AZ"Arial Regular _^s_XXQ^s__^s (  1.Provideadetailedexplanationofthescientificandbudgetaryrelationshipofeachprogram/projectlistedon_VAF_Ԁ1013137  ЀtotalVAProgram.2.Incolumnbelowlabeled STATUS,insertoneofthefollowing:VA(VA):G(government):NG(nongovernment):P(pending).#^s__Q^s/##XV0X_^s# ("  _  9X_XXX94 X9X_INVESTIGATORSTOTALVAANDNONVARESEARCH/DEVELOPMENTSUPPORT#9X_X 94V#,  AZ"Arial Regular _^s_XX<^s__^sINSTRUCTIONS:#^s__<^s/##XV0X_^s# _,x,XX1,,,,x (  VAForm  Jun1990#,x,,1,/#,  AZ"Arial Regular _^s_XXF^s__^s (  GRANT/PROJECTTITLE#^s__F^s/##XV0X_^s# _  AX_XXXA^s_XAX_ (  STATUS#AX_X_A^s;##XV0XXAX_#@@@@'dxd d,  AZ"Arial Regular _  CX_XXXC^s_XCX_ (  STATUS#CX_X_C^s;##XV0XXCX_#,  AZ"Arial Regular _^s_XXH^s__^s (  GRANT/PROJECTNO.#^s__H^s/##XV0X_^s#,  AZ"Arial Regular,  AZ"Arial Regular _^s_XXC^s__^s (  GRANT/PROJECTNO.#^s__C^s/##XV0X_^s# _^s_XXC^s__^s (  GRANT/PROJECTTITLE#^s__C^s/##XV0X_^s# ("  _gXX MV}g1013138#gMV}M#  _,x,XX (  O,,,,xPage8#,x,,O,J##XV0X,,x#- AZ"Arial Regular,  AZ"Arial Regular,  AZ"Arial Regular _^s_XX^s__^s ^s__^sNAME (  #^s__ ^sN##X_X_^s#,  AZ"Arial Regular,  AZ"Arial Regular !  _XX ABLORDEPPEY,SethY.G0  R15,AI37976010  0%% NovelAntifungalAgentsAgainOpportunisticInfections %% Theprimarygoalofthisprojectistomodifythestructureofanaturalproductcalled_cryptolepine_,whichwasisolatedfromtheplant_Cryptolepis_Ԁ_sanguinolenta_.Therationaleforthestructuremodificationrelatestoour @ 8  needtoidentifythestructuralelementsthatcontributetoitsantifungalactivity.Therearenobudgetaryorscientificoverlapswiththecurrentproposal.G0  2506GM0811250 %%0 % %0h%%h%h% Thisprojectisbasedonthehypothesisthatthelongtermtoxicityassociatedwiththe_antipsychotic_Ԁdrug,_haloperidol_,maybeduetoits_biotransformation_Ԁto_MPP_+likespeciesinthebrain.Thus,analogsof_haloperidol_whichcannotfor_MPP_+likemetaboliteswereproposedasalternativesto_haloperidol_Ԁbutwithoutthelongtermirreversible_extrapyrimidal_Ԁactions.Therearenobudgetaryorscientificoverlapswiththecurrentproposal.     `     h      p _ABLORDEPPEY_,SethY.  0  0` %%0 ` %` %0 % %0h%%0h%h%0%% SynthesisandStructureActivityRelationship\,T+/%% P     `    StudiesofNovelAntifungalAgentsAgainst_OIs_ԀAssociatedwithAIDS H-@,0 ThisprojecthassimilargoalsastheR15projectwhichexpiresinMay,1998.Itsimmediategoalistostudythestructureactivityrelationshipof_cryptolepine_Ԁinordertounderstandthestructuralcharacteristicsandrequirementsforitsantifungalactivity.Itishopedthatwewouldidentifynewandnovelagentsasreplacement 0/4 forthecurrentstandardagentAmphotericinBwithitsextensivetoxicities.Thereisnobudgentaryorscientifiecoverlapwtiiththiecurrentproposal.h